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2006 1
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2009 3
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2013 2
2014 5
2015 3
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2020 5
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Page 1
House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.
Serhan N, Basso L, Sibilano R, Petitfils C, Meixiong J, Bonnart C, Reber LL, Marichal T, Starkl P, Cenac N, Dong X, Tsai M, Galli SJ, Gaudenzio N. Serhan N, et al. Nat Immunol. 2019 Nov;20(11):1435-1443. doi: 10.1038/s41590-019-0493-z. Epub 2019 Oct 7. Nat Immunol. 2019. PMID: 31591569 Free PMC article.
Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. . …
Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nocicep …
Biochemistry, Substance P.
Graefe SB, Rahimi N, Mohiuddin SS. Graefe SB, et al. 2023 Jul 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 30. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32119470 Free Books & Documents.
SP is a member of the tachykinin (TAC) family of neuropeptides encoded by the TAC1 gene. SP elicits its activity via interacting with the G protein-coupled neurokinin receptors (NKRs), including NK1R, NK2R, and NK3R. ...Emerging evidence suggests that substance P plays oth …
SP is a member of the tachykinin (TAC) family of neuropeptides encoded by the TAC1 gene. SP elicits its activity via interacting with …
Substance P and fibrotic diseases.
Peng L, Agogo GO, Guo J, Yan M. Peng L, et al. Neuropeptides. 2019 Aug;76:101941. doi: 10.1016/j.npep.2019.101941. Epub 2019 Jun 24. Neuropeptides. 2019. PMID: 31256921 Review.
Substance P (SP) is an undecapeptide encoding the tachykinin 1 (TAC1) gene and belongs to the tachykinin family. SP is widely distributed in the central nervous system and the peripheral nervous system. ...
Substance P (SP) is an undecapeptide encoding the tachykinin 1 (TAC1) gene and belongs to the tachykinin family. SP is widely distrib …
Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma.
Tiotiu A, Badi Y, Kermani NZ, Sanak M, Kolmert J, Wheelock CE, Hansbro PM, Dahlén SE, Sterk PJ, Djukanovic R, Guo Y, Mumby S, Adcock IM, Chung KF; U-BIOPRED Consortium Project Team. Tiotiu A, et al. Am J Respir Crit Care Med. 2022 Feb 15;205(4):397-411. doi: 10.1164/rccm.202102-0355OC. Am J Respir Crit Care Med. 2022. PMID: 34813381
Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive immunity, but their involvement in severe asthma (SA) remains undefined. ...A FcepsilonR1-IgE-stimulated and a single-cell signature from asthmatic bronchial biopsies were highly enriched …
Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive immunity, but their involvement in severe asthma …
Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism: a case-control study.
Marui T, Funatogawa I, Koishi S, Yamamoto K, Matsumoto H, Hashimoto O, Nanba E, Nishida H, Sugiyama T, Kasai K, Watanabe K, Kano Y, Kato N, Sasaki T. Marui T, et al. Brain Dev. 2007 Sep;29(8):510-3. doi: 10.1016/j.braindev.2007.01.010. Epub 2007 Mar 21. Brain Dev. 2007. PMID: 17376622 Clinical Trial.
These products modulate glutamatergic excitatory synaptic transmission and are also involved in inflammation. Many different inflammation-related mechanisms could be involved in the autistic brain. Therefore, TAC1 may have some functions associated with the p …
These products modulate glutamatergic excitatory synaptic transmission and are also involved in inflammation. Many different infla …
Role of Pituitary Adenylate-Cyclase Activating Polypeptide and Tac1 gene derived tachykinins in sensory, motor and vascular functions under normal and neuropathic conditions.
Botz B, Imreh A, Sándor K, Elekes K, Szolcsányi J, Reglődi D, Quinn JP, Stewart J, Zimmer A, Hashimoto H, Helyes Z. Botz B, et al. Peptides. 2013 May;43:105-12. doi: 10.1016/j.peptides.2013.03.003. Epub 2013 Mar 13. Peptides. 2013. PMID: 23499760
Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. ...Basal postope …
Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are …
The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis.
Cunningham S, O'Doherty C, Patterson C, McDonnell G, Hawkins S, Marrosu MG, Vandenbroeck K. Cunningham S, et al. J Neuroimmunol. 2007 Feb;183(1-2):208-13. doi: 10.1016/j.jneuroim.2006.11.002. Epub 2006 Dec 18. J Neuroimmunol. 2007. PMID: 17175032
Analysis of these SNPs in the Sardinians was not significant though a similar trend to that originally observed in the Northern Irish was present. Meta-analysis of the Sardinian and Northern Irish TAC1 SNP genotype data revealed a Mantel-Haenszel Common OR Estimate for the …
Analysis of these SNPs in the Sardinians was not significant though a similar trend to that originally observed in the Northern Irish was pr …
Role of substance P in the cardiovascular system.
Mistrova E, Kruzliak P, Chottova Dvorakova M. Mistrova E, et al. Neuropeptides. 2016 Aug;58:41-51. doi: 10.1016/j.npep.2015.12.005. Epub 2015 Dec 8. Neuropeptides. 2016. PMID: 26706184 Review.
This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions o …
This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular r …
Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones.
Shanley L, Lear M, Davidson S, Ross R, MacKenzie A. Shanley L, et al. J Neuroinflammation. 2011 Feb 4;8:10. doi: 10.1186/1742-2094-8-10. J Neuroinflammation. 2011. PMID: 21294877 Free PMC article.
The neuropeptide substance-P (SP) is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic inflammation. The promoter of TAC1 (TAC1prom) plays a central role in the regulation of the TAC1 gene but requires the …
The neuropeptide substance-P (SP) is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic …
A Hypothalamic-Controlled Neural Reflex Promotes Corneal Inflammation.
Lasagni Vitar RM, Fonteyne P, Chaabane L, Rama P, Ferrari G. Lasagni Vitar RM, et al. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):21. doi: 10.1167/iovs.62.13.21. Invest Ophthalmol Vis Sci. 2021. PMID: 34698773 Free PMC article.
TAC1-KO mice showed a reduced number of cFOS+/NK1R+/TH+ presympathetic neurons (P < 0.05) paralleled by higher nNOS expression (P < 0.05) in both PVH and LHA. A decrease in activated sympathetic neurons in the SCG and NA levels in both cornea/bone marrow and reduced …
TAC1-KO mice showed a reduced number of cFOS+/NK1R+/TH+ presympathetic neurons (P < 0.05) paralleled by higher nNOS expression (P …
55 results